Ask Erowid

Ask a Question

Find an answer:

View By Category

Search Ask Erowid
Search Vaults

Enter a keyword in the search field above to look up a question or answer on a specific topic.

Off-Site Psychoactive Question Resources
  Ask Dr Shulgin

Resources at Erowid
  Plants & Drugs
  Freedom & Law
  Mind & Spirit
  Arts & Sciences
  Library / Bookstore
  What's New
  About Erowid
Can a protein ever cross the blood-brain barrier?
Q: What kind of chemical manipulation would it take to render a protein able to cross the blood-brain barrier?

Are proteins ever used as CNS drugs?

A: It is very unlikely that a protein would ever cross the so-called blood-brain barrier (BBB). The BBB has very stringent size and charge limitations, which would prohibit large charged macromolecules like proteins from crossing.

While there are psychoactive peptides and protein modulators of signalling pathways, I do not know of any use of a protein or peptide as a CNS drug.



Asked By : brdrline
Answered By : psilo
Published Date : 10 / 15 / 2002
Last Edited Date : 10 / 15 / 2002
Question ID : 2997

Categories: [ Pharmacology ]

Ask Erowid v1.7 - Jul, 2005

(content and html © the Vaults of Erowid. Please ask permission before publicly reproducing.)