Can Butyric acid be used as a replacement for GBL in GHB synthesis?
|Can Butyric acid be used as a replacement for GBL in the GHB synthesis?
|No. The synthesis of GHB from GBL is a simple ring-opening of a lactone, yielding a hydroxy-butyric acid. Using GBL as the precursor is by far the easiest method. Attempting to use butyric acid in a typical GBL -> GHB synthesis will give you nothing but a sodium or potassium salt of butyric acid, which should have little to no activity.
In order to use butyric acid to make GHB, you would have to add a hydroxyl group to the end opposite the carboxylic acid (the COOH). While there are several ways this can be done, they are somewhat complex and require several additional steps.
[ Chemistry ]
[ GHB ]