Can Butyric acid be used as a replacement for GBL in GHB synthesis?
||Can Butyric acid be used as a replacement for GBL in the GHB synthesis?|
||No. The synthesis of GHB from GBL is a simple ring-opening of a lactone, yielding a hydroxy-butyric acid. Using GBL as the precursor is by far the easiest method. Attempting to use butyric acid in a typical GBL -> GHB synthesis will give you nothing but a sodium or potassium salt of butyric acid, which should have little to no activity.|
In order to use butyric acid to make GHB, you would have to add a hydroxyl group to the end opposite the carboxylic acid (the COOH). While there are several ways this can be done, they are somewhat complex and require several additional steps.
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