Ask Erowid

Ask a Question

Find an answer:

View By Category

Search Ask Erowid
Search Vaults

Enter a keyword in the search field above to look up a question or answer on a specific topic.

Off-Site Psychoactive Question Resources
  Ask Dr Shulgin

Resources at Erowid
  Plants & Drugs
  Freedom & Law
  Mind & Spirit
  Arts & Sciences
  Library / Bookstore
  What's New
  About Erowid
How can 5-MeO-DMT be converted to DMT?
Q: Dear Erowid,
Any ideas how easily 5MEO-DMT can be converted into DMT freebase?

A: This would be somewhat problematic to do chemically I would think. You would first have to remove the methyl from the methoxide, then dehydrate the hydroxl off the phenyl ring. The latter is often a very vigorous reaction and would likely give you many side products.

Ideally, one could do this enzymatically. By either identifying the enzymes that hydroxylate and then methoxylate DMT (or its precursors), or by identifying an enzyme that is designed to remove these groups (without further destruction of the compound), you could just mix the enzyme and drug together in the right buffer and extract/separate out your desired product. Still, this is completely hypothetical and would require a good deal of research that has yet to be done.

Simply put, we are not aware of any practical method for converting 5MeO-DMT to N,N-DMT.



Asked By : Rami
Answered By : psilo
Published Date : 3 / 20 / 2001
Last Edited Date : 3 / 20 / 2001
Question ID : 2347

Categories: [ Chemistry ]

Ask Erowid v1.7 - Jul, 2005

(content and html © the Vaults of Erowid. Please ask permission before publicly reproducing.)