Any ideas how easily 5MEO-DMT can be converted into DMT freebase?
||This would be somewhat problematic to do chemically I would think. You would first have to remove the methyl from the methoxide, then dehydrate the hydroxl off the phenyl ring. The latter is often a very vigorous reaction and would likely give you many side products.|
Ideally, one could do this enzymatically. By either identifying the enzymes that hydroxylate and then methoxylate DMT (or its precursors), or by identifying an enzyme that is designed to remove these groups (without further destruction of the compound), you could just mix the enzyme and drug together in the right buffer and extract/separate out your desired product. Still, this is completely hypothetical and would require a good deal of research that has yet to be done.
Simply put, we are not aware of any practical method for converting 5MeO-DMT to N,N-DMT.
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