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Proal AC, Fleming J, Galvez-Buccollini JA, Delisi LE. 
“A controlled family study of cannabis users with and without psychosis”. 
Schizophr Res. 2013 Dec 6.

BACKGROUND: Cannabis is one of the most highly abused illicit drugs in the world. Several studies suggest a link between adolescent cannabis use and schizophrenia. An understanding of this link would have significant implications for legalization of cannabis and its medicinal value. The present study aims to determine whether familial morbid risk for schizophrenia is the crucial factor that underlies the association of adolescent cannabis use with the development of schizophrenia.

METHODS: Consecutively obtained probands were recruited into four samples: sample 1: 87 non-psychotic controls with no drug use sample 2: 84 non-psychotic controls with cannabis use sample 3: 32 patients with a schizophrenia spectrum psychosis with no drug use sample 4: 76 patients with schizophrenia spectrum psychosis with cannabis use. All cannabis using subjects used this drug during adolescence, and no other substance, with the exception of alcohol. Structured interviews of probands and family informants were used to obtain diagnostic information about probands and all their known relatives.

RESULTS: There was an increased morbid risk for schizophrenia in relatives of the cannabis using and non-using patient samples compared with their respective non-psychotic control samples p=.002, p<.001 respectively. There was no significant difference in morbid risk for schizophrenia between relatives of the patients who use or do not use cannabis p=.43.

CONCLUSIONS: The results of the current study suggest that having an increased familial morbid risk for schizophrenia may be the underlying basis for schizophrenia in cannabis users and not cannabis use by itself.
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