Plants - Drugs Mind - Spirit Freedom - Law Arts - Culture Library  
Erowid References Database
Pan HS, Wang RY. 
“MDMA: further evidence that its action in the medial prefrontal cortex is mediated by the serotonergic system”. 
Brain Res. 1991;539(2):332-6.
Systemically administered (+/-)-MDMA (3,4-methylenedioxymethamphetamine, 'Ecstasy') suppressed the firing rates of the majority of neurons in the medial prefrontal cortex (mPFc). The responses of mPFc cells to (+/-)-MDMA is mimicked by (+)-MDMA but not (-)-MDMA. Furthermore, pretreatment with fluoxetine (a specific 5-HT uptake blocker) but not GBR 12909 (a specific dopamine uptake blocker) prevented the suppressant action of MDMA. These data support the notion that the 5-HT system mediates (+/-)-MDMA's action.

Comments and Responses to this Article
Submit Comment
[ Cite HTML ]