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Friedhoff AJ, Van Winkle E. 
“Isolation and characterization of a compound from the urine of schizophrenics”. 
Nature. 1962 Jun 2;194(4831):898-9.
The systematic screening of schizophrenic and normal urine in this laboratory has led to the identification of a biologically active compound in urine of schizophrenics. This compound is of particular interest since it does not have the usual sympathomimetic actions of the closely related catecholamines, but does have a depressant effect on the central nervous system.
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