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Darmani NA, Martin BR, Glennon RA. 
“Withdrawal from chronic treatment with -DOI causes super-sensitivity to 5-HT2 receptor-induced head-twitch behaviour in mice”. 
Eur J Pharmacol. 1990 Sep 15;186(1):115-8.
Mice were injected once daily for 13 days with -DOI -1-2,5-dimethoxy-4-iodophenyl-2-aminopropane and the induced head-twitch response HTR was scored. On days 2-5 HTR was reduced to less than 50 of day 1, and then returned to control levels by day 13. Challenge doses of -DOI administered on days 15, 17 or 19 elicited significantly exaggerated responses. Thus, chronic treatment with -DOI may cause an initial down-regulation followed by an up-regulation of 5-HT2 receptor function after cessation of such treatment.
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