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Morgan M, Mandell AJ. 
“Indoleethylamine N-methyltransferase in the brain”. 
Science. 1969 Aug 24;165(892):492-3.
An enzyme which N-methylates various indoleethylamine substrates was isolated from brain, separated from the pituitary and the pineal glands. It appeared localized in the supernatant and synaptosomal areas after discontinuous sucrose-gradient ultracentrifugation. This is the first demonstration of the enzyme in brain.
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