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Saavedra JM, Axelrod J. 
“Psychotomimetic N-methylated tryptamines: formation in brain in vivo and in vitro”. 
Science. 1972 Mar 24;175(28):1365-6.
The use of a sensitive enzymatic assay demonstrates that tryptamine occurs normally in rat brain. Intracisternal administration of [14C]tryptamine results in the formation of N-methyl-and dimethyltryptaminea psychotomimetic compoundin the rat brain. An enzyme that converts tryptamine and N-methyl-tryptamine to N-methyl-and dimethyltryptamine was found to be present in rat and human brain. The N-methylation of tryptamine was inhibited by normally occurring compounds present in rat brain.
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