Erowid References Database
“Ecstasy use and neuropathology”.
Br J Psychiatry. 1999;175:589.
Obrocki et al (1999) claim to reveal long-terxn effects of methylenedioxymethamphetamine (MDMA) on the central nervous system in a study of seven subjects, but in fact repeat the errors of previous published studies of neurotoxicity in humans (McCann et al, 1998). McCann et al provided convincing evidence of an association between decreased serotonin (5-HT) transporter binding sites and MDMA use, and Obrocki et al demonstrate an association between MI)MA use and altered glucose metabolic uptake in Brodmann's area 11 in particular. However, association does not imply causation, and the findings could not imply causation, and the findings could be explained in terms of neuropathology or both arising from common denominator.
Both Obrocki et al and McCann et al focus exclusively on the first hypothesis to the detriment of their otherwise convincing results.
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