Plants - Drugs Mind - Spirit Freedom - Law Arts - Culture Library  
Erowid References Database
Ashby CR, Edwards E, Harkins K, Wang RY. 
“Effects of (+/-)-DOI on medial prefrontal cortical cells: a microiontophoretic study”. 
Brain Res. 1989 Oct 17;498(2):393-6.
The relatively selective 5-HT2 receptor agonist, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane [+/-)-DOI) ejected by microiontophoresis at low currents potentiates glutamate (GLU)-induced excitation and at higher currents (greater than 20 nA) invariably inhibits both spontaneous and GLU-induced activity of cells in the medial prefrontal cortex (mPFc). The inhibitory action of DOI is blocked by the 5-HT2 antagonists, ritanserin, metergoline and spiperone, but not other receptor antagonists. Microiontophoresis of 1 M Mg2+ for 5-20 min did not alter DOI's inhibitory effect suggesting that DOI's action is a direct one. These results show that DOI predominantly inhibits mPFc neuronal activity and this inhibitory action is mediated by 5-HT2 receptors.
Comments and Responses to this Article
Submit Comment
[ Cite HTML ]