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Farah R, Farah R. 
“Ecstasy (3,4-methylenedioxymethamphetamine)-induced inappropriate antidiuretic hormone secretion”. 
Pediatr Emerg Care. 2008 Sep 17;24(9):615-7.
3,4-Methylenedioxymethamphetamine (MDMA), popularly known as the illicit drug "Ecstasy," is an amphetamine derivative that has become widely abused throughout the United States and other industrialized nations. 3,4-Methylenedioxymethamphetamine has an undeserved reputation as a "safe" drug among its users, but MDMA shares the toxicity profile of other amphetamines. Its use may result in lethal cardiovascular, hepatic, metabolic, or neurological toxicity. The syndrome of inappropriate secretion of antidiuretic hormone (SIADH) is a unique toxicity that may occur after isolated MDMA use. Although the phenomenon is well described in adults, reports of MDMA-induced SIADH and symptomatic hyponatremia in children are rare. We describe a 13-year-old girl who experienced MDMA-induced SIADH with symptomatic hyponatremia. Toxicity of MDMA, in particular, the pathophysiology and treatment of MDMA-induced hyponatremia, is discussed.
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Apr 17, 2011 1:59
Extremely Unusual #

This is an extremely unusual report of hyponatremia after ecstasy ingestion. This 13-year-old girl reported to the hospital 60 hours after being at a party where she took MDMA (confirmed by GC/MS from blood). She reportedly had serum glucose levels low enough at the time that the ED staff administered orange juice which measurably returned her glucose levels. They also reported continued bruxism and dilated pupils 2 days after ingestion, something which is unheard of in the medical literature or experience reports.
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