Plants - Drugs Mind - Spirit Freedom - Law Arts - Culture Library  
Erowid References Database
Louw DF, Yang FW, Sutherland GR. 
“The effect of delta-9-tetrahydrocannabinol on forebrain ischemia in rat”. 
Brain Res. 2000 Feb 28;857(1-2):183-7.
The purpose of the study was to evaluate the effect of delta-9-tetrahydrocannabinol (THC), the major psychoactive constituent of marijuana, on ischemic neuronal injury. A 12-min ischemic insult was induced by a reduction in systolic blood pressure to a mean of 50 mm Hg, followed by bilateral carotid artery occlusion at a middle ear temperature of 37.5 degrees C. THC at either a low (0.1 mg/kg; n=8) or high (10 mg/kg; n=8) dose was injected i.p. every 12 h for 7 days prior to ischemia. Non-treated ischemic (n=8) animals formed the control group. The animals were sacrificed 3 weeks post-ischemia for quantitative histopathology. THC at either dose did not significantly reduce ischemic neuronal damage in the hippocampus. The high dose THC-treated group showed significantly less neocortical injury, compared to either the control or low-dose THC groups (p< 0.05). The striatum was markedly protected by both low and high dose THC (p< 0.001). This regionally specific protection implies that either the hippocampus undergoes suprathreshold ischemic injury or that mechanisms of ischemic injury vary in different brain regions.
Comments and Responses to this Article
Submit Comment
[ Cite HTML ]