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Winstock AR, King LA. 
“Ecstasy and neurodegeneration. Tablets often contain substances in addition to, or instead of, ecstasy.”. 
BMJ. 1996 Aug 17;313(7054):423-4.
Those who metabolise the drug quickly may possibly also experience 'desirable' effects of the drug for a shorter time than other people. This might lead them to take increasing doses to sustain the wanted effect, with this compounding any potential risk. In a study at the Maudsley Hospital many subjects have reported taking over 10 tablets in an evening; some have reported lifetime use exceeding 1000 tablets. With toxicity in animal studies being associated with a single dose,4 such lifetime consumption makes the likelihood of latent functional psychological problems even more likely.
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