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Tilson HA, Sparber SB. 
“Similarities and differences between mescaline, lysergic acid diethylamide-25 (LSD) and d-amphetamine on various components of fixed interval responding in the rat”. 
J. Pharmacol. exp. Ther.. 1973;184:376-384.
Three male albino rats were trained to lever press fo food on a fixed-interval 75-second schedule of reinforcement. Responding in the first and last 15 seconds of the interval, as well as overall response rates, were analyzed. After stabilization of fixed-interval responding the effects of lysergic acid diethylamide-25 (LSD) (0.005-0.150 mg/kg), d-amphetamine sulfate (0.10-0.96 mg/kg) and mescaline hydrocholoride (1-12 mg/kg) o fixed interval responding were investigated. LSD (0.015 mg/kg) increased responding in all portions of the interval, whereas higher doses tended to decrease responding. d-Amphetamine (0.15 and 0.48 mg/kg) increased rates of responding except at the highest dose (0.96 mg/kg) which decreased responding in the last portion of the interval. In rats tolerant to the effects of mescaline (3 mg/kg), there were indications of cross-tolerance to the effects to 0.15 mg of d-amphetamine per kg, but no cross-tolerance was observed when the order of drug presentation was reversed. A two-way, partial cross-tolerance was observed between the effects of 0.045 mg of LSD per kg and 3 mg of mescaline per kg and rats tolerant to the effects of 0.015 mg of LSD per kg did not show cross tolerance to the effects of 0.15 mg of d-amphetamine per kg regardless of the order of drug presentation. These data suggest mescaline shares common mechanisms or components of behavioral action with both LSD and d-amphetamine in the rat.
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