Erowid References Database
Korein J, Musacchio JM.
“LSD and focal cerebral lesions”.
The effect of d-lysergic acid diethylamide 25 (LSD) in producing hallucinations and distortions involving visual, auditory, and somatic sensation in the normal human subject is well documented. In patients with focal cerebral disease, drugs such as amobarbital may induce focal weakness and pentylenetetrazol (Metrazol) or bemegride may produce focal seizures. The unmasking of latent defects with these agents leads to the consideration that LSD may cause specific sensory changes related to focal cerebral lesions. If such specific sensory changes could be validated, one might use the drug clinically for localization of lesions or experimentally for gaining insight into its mode and locus of activity. Studies of the effect of LSD on human subjects with focal organic central nervous system disease are limited. This study evaluates the behavioral and electroencephalographic effects of LSD in 14 patients with sensory disorders due to focal cerebral diseases.
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