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Hjorthl S, Carlssoni A, Lindberg P, Sanchez D, Wikström H, Arvidsson LE, Hacksell U, Nilsson JLG. 
“8-Hydroxy-2-(Di-n-Propylamino)Tetralin, 8-OH-DPAT, a Potent and Selective Simplified Ergot Congener with Central 5-HT-Receptor Stimulating Activity”. 
J. Neural Transmission. 1982;55:169-188.
It was demonstrated that the simplified ergot congener 8-hydroxy-2-(di-n-propylamino)tetralin, 8-OH-DPAT, is able to elicit pronounced biochemical and behavioural alterations indicative of central serotoninomimetic activity. Since these effects are resistant to prior monoamine depletion and/or synthesis inhibition by means of reserpine and alpha-propyldopacetamide (H22/54), respectively, they are most likely to be attributable to direct serotonin receptor agonism by 8-OH-DPAT. With regard to central 5-HT neurotransmission the effects of 8 OH-DPAT increased 5-HT levels, decreased 5-HIAA levels, 5-HT-synthesis rate and 5-HT utilization and inhibited 5-HT neuronal firing are virtually identical, and comparable in potency, to those reported to result from the administration of lisuride or LSD. In contrast, however, to lisuride and LSD (included for comparative purposes in this study) as well as to several differently N-substituted, 5,6-dihydroxy, 6,7-dibydroxy and 5-,6- and 7-monohydroxy 2-aminotetralins, 8-OH-DPAT lacks appreciable effects on
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