Erowid References Database
Maj J, Baran L, Rawlow A, Sowinska.
“Central effects of miaserin and danitracen - New antidepressants of unknown mechanism of action”.
The influence of dopamininergic agents on serotoninergic neurons is presented. Apomorphine (AP), 1,3-dimethyl-5-aminoadamantane (DMAA) and piribedil (PB) all induce behavioral excitation, possess antineuroleptic properties and induce hypotension which is not altered by atropine, p-blockers and antihistamines but is antagonized by spiroperidol. PB affects noradrenaline neurons but AP and DMAA do not. AP increases brain 5-HT and 5-HIAA levels, increases the disappearance rate of 5-HT and intensifies the 5-HT fluorescence in the raphe nuclei. DMAA reduces 5-HT levels increases 5-HIAA levels, reduces fluorescence of 5-HT and does not affect the rate of disappearance of 5-HT. PB induces slight increases in 5-HT and 5-HIAA levels and does not affect fluorescence of 5-HT, AP, DMAA and PB all inhibit ponto-geniculooccipitalis bioelectrical activity induced in cats by Ro4-lZ48. The dopaminergic agents induce hypothermia in rats and mice similarly to L-dopa (after inhibition of peripheral decarboxylase). DA blockers antagonize the hypothermic effects of dopaminergic agents in rabbits but not that of L-dopa. The hypothermic effect of AP or L-dopa is attenuated by raphe nuclei lesions but is unaffected by atropine. LSD antagonizes increases of 5-HIAA induced by AP or L-dopa and the hypothermic effects of these agents. AP, DMAA and PB induce hypothermia in rabbits. p-Chlorophenylalanine and pimozide antagonize this effect of AP. Locomotor stimulation induced by amphetamine or AP is intensified by raphe nuclei lesion or p-chloroamphetamine. Conclusions Agents which stimulate DA receptors may influence secondarily 5-HT neurons and thus the interaction between dopaminergic and serotoninergic systems would exist. This may be of significance for different pharmacological effects seen after administration of dopaminergic agents.
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