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Ksir CJ. 
“Rate-Dependent and Stimulus Control Effect of Drugs”. 
Psychopharmacol.Bull.. 1978;14(I):66-67.
The rate-dependent and stimulus control effects of LSD and amphetamine were studied in rats. Methods The effects of the 2 drugs on fixed-interval (FI) responding was evaluated by depriving rats of food and training them to press a key that produces a food pellet after a 3 min interval. 10 Such intervalswereusedin the daily sessions, and graded doses of the test drug were administered 30 min before sessions. In a similar test, a multiple fixed-interval/fixed-ratio (FIFR) schedule was used, with the FR component involving the delivery of a food pellet after 30 responses. Finally, rats were trained on a FI reinforcement schedule after administration of d-amphetamine until a stable performance was obtained, Saline was then substituted for the d-amphetamine to determine ratedependent effects. Results Amphetamine (0.5-2.0 mg/kg) did not significantly alter the overall response rate in the FI study, but it produced a doserelated disruption in the response pattern. LSD (0.04-1.28 mg/kg) showed the opposite effect, decreasing the overall response rate at doses of 0.32 mg/kg, but not disrupting the typical FI pattern of response except at the highest dose. In the FIFR study, aphetamine (1.0 mg/kg) significantly increased FR responding, whereas LSD (0.08-0.32 mg/kg) nonsignificantly reduced FR responding. Rate-dependent changes in responding occurred in 3/6 rats switched from amphetamine (1.0 mg/kg) to saline; with low rates being increased and high rates being decreased Results are discussed.
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