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Fertziger AP, Fischer R. 
“Interaction Between Narcotic Antagonist (Naloxone) and Lysergic Acid Diethylamide (LSD) in the Rat”. 
Psychopharmacology. 1977;54(3):313-14.
A possible antagonistic interaction between LSD and naloxone was investigated in rats. LSD (375 mcg/kg) administration in rats (280-320 g) elicited a diphasic reaction consisting of a brief excitable period (up to 8 min) followed by a prolonged catalepsy (8 min-1 hr). While the cataleptic response was antagonized by a single injection of naloxone (Endo, 0.2 mg/kg. i.m. given 30 min after LSD administration), pretreatment with nalaxone shortened the excitable phase and potentiated the catalepsy.
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