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Belanger M, Chibon P, Coulomb M. 
“Etude radiologique des effets du LSD-25 sur l'amphibien pleurodeles waltlii Michah. Comparaisons entre individus témoins et individus issus de mâles traités au LSD-25”. 
Compt.Rend.Soc.Biol.. 1976;169(6):1518-1521.
The effect of the LSD-25 treatment of males on their subsequent offspring was investigated radiologically in the amphibian Pleurodeles waltlii Michah. Methods Male amphibia were given 5 mcg/day LSD-25 i.p. for 60 days 1 yr before being mated with untreated females. The limbs vertebrae, ribs and pelvic girdle of the progeny were examined radiologically and the incidence of skeletal anomalies compared with that in the controls. Results In the LSD descendants anomalies were present in the hands in 28% and in the feet in 21%, the corresponding figures in the controls being 13% and 35% respectively. There were vertebral anomalies in 350f LSD descendants and in only 60f controls. Rib anomalies occurred in 390f LSD descendants and 210f controls, while pelvic malformations were present in 470f LSD descendants and 310f controls. Only 35.60f all LSD descendants had a completely normal vertebral column with normal ribs and pelvis, whereas 60.40f controls did so. A radiological picture characteristic of vitamin C and D deficiency in mammals was seen in the majority of the X-rays, including those of the controls, that of ascorbic acid deficiency being seen mainly in the carpus and tarsus and that suggestive of disturbances of the metabolism of 7-dehydrocholecalciferol in the long bones. Conclusions Apart from anomalies affecting the legs, which were more frequent in the controls, the incidence of skeletalanomalies was about twice as high in the LSD descendants as in the controls. The LSD-25 treatment is thought to have encouraged the appearance of hereditary morphological anomalies already latent in the species.
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