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Goetz P, Sram RJ, Zudová Z. 
“The Mutagenic Effect Of Lysergic Acid Diethylamide: I. Cytogenetic Analysis”. 
Mutation Res. 1974;26:513-516.
The effect of lysergic acid diethylamide (LSD) was studied in rats and mice by analysing chromosomes of primary spermatocytes. Male Wistar rats received a single dose of LSD (10 or 1000 mcg/kg b.w.). The spermatocytes in diakinesis first metaphase were analysed on day 1, 7, 21 and 41 after the administration. ICR male mice were treated by a dose Or 1000 mcg LSD/kg b.w.

A testicular analysis was made after 12 weeks. Chromosomal breaks Mere sporadic and non-significant, with no chromosome rearrangements. A significant increase of spermatocytes, with univalents, in comparison with controls, was found in all experimental groups. Rats showed a distinct increase in the occurrence of spermatocytes With autosomal univalents; in mice there was an increased frequency of autosomal as well as X-Y unit alerts.

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