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Lerner AG, Skladman I, Kodesh A, Sigal M, Shufman E. 
“LSD-induced Hallucinogen Persisting Perception Disorder treated with clonazepam: two case reports”. 
Isr J Psychiatry Relat Sci. 2001;38(2):133-6.
Abstract
Benzodiazepines are recommended for the treatment of Hallucinogen Persisting Perception Disorder (HPPD), although it is unclear which may be more helpful. Two out-patients with LSD-induced HPPD were successfully treated with clonazepam. They had not responded to low potency benzodiazepines or low doses of classic antipsychotics. After clonazepam discontinuation they reported a marked improvement and only mild symptomatology which persisted during a six month follow-up period. High potency benzodiazepines like clonazepam, which has serotonergic properties, may be superior to low-potency benzodiazepines in the treatment of some patients with LSD-induced HPPD.

Lev Hasharon Mental Health Medical Center, Pardessya, Israel. lerneram@internet-zahav.net
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