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Matthai SM, Davidson DC, Sills JA. 
“Cerebral oedema after ingestion of MDMA ('ecstasy') and unrestricted intake of water [Authors' reply]”. 
BMJ. 1996 Sep 14;313:690.
We thank T M Cook, Barry Wilkins, and Emily Finch and colleagues for their comments. We acknowledge the typographical error in the measured plasma osmolalities, which should indeed be 256 mmol/kg in case 1 and 242 mmol/kg in case 2. The point of our letter was to stimulate debate on the potential harm of unlimited intake of fluid in users of 3, 4-methylenedioxymethamphetamine (MDMA or 'ecstasy') and the danger to unsupervised children. Note that high fluid intake is still often encouraged in clubs and 'rave' scenes. It is not known how much water intake is safe in terms of combatting dehydration while avoiding fluid overload, hyponatraemia, and possible cerebral oedema.
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