Review Erowid at!
Help us be a "Top Rated Nonprofit" for the 10th year in a row
and spread info about psychoactive drugs, health, culture, & policies.
("Share Your Story" link. Needs quick login creation but no verification of contact info)
Possible Potentiation
Pharmahuasca (Syrian Rue & DMT) & Buprenorphine
by nueronaut
Citation:   nueronaut. "Possible Potentiation: An Experience with Pharmahuasca (Syrian Rue & DMT) & Buprenorphine (exp91053)". Dec 22, 2020.

T+ 0:00
4 mg sublingual Pharms - Buprenorphine (daily)
  T+ 0:00 250 mg oral Syrian Rue (extract)
  T+ 0:00 250 mg oral Syrian Rue (extract)
  T+ 0:30 100 - 150 mg oral DMT (extract)
  T+ 0:00   repeated smoked Cannabis  


Prior to this a friend had extracted about a gram of DMT from fifty grams of mimosa root bark. He had also extracted harmala alkaloids from syrian rue to act as the MAOI needed to orally activate the DMT. Both extractions were successful and relatively simple, a stb extraction on the bark and a salt saturation extraction on the rue.

I had been on buprenorphine for pain prior to this experience. I had experimented with smoking very low amounts of the DMT to get a feel for it.
I had experimented with smoking very low amounts of the DMT to get a feel for it.
I noticed that even extremely small amounts affected me rather strongly so I began to suspect that the bupe might be potentiating the DMT. I havenít stopped taking the bupe in order to try the DMT without it but plan to soon, as I would really like to get a comparison of the effects. Anyways, I didnít like how fast and strong DMT was when smoked it just didnít seem like it was the proper method for learning from it, I wanted a slower experience so I figured Pharmahuasca was the way to go. I have had experience with more drugs than I care to list, just about everything but PCP, crack, and real heroin although Iíve done narcotics nearly as strong and some perhaps even stronger. As far as psychedelics go Iíve tripped on LSD and mushrooms several times and one week trip on mescaline. Worth mentioning also are salvia and ketamine simply because DMT had effects which reminded of both of those but obviously much different in its overall character. Smoking D hits me like salvia and feels uncomfortable for me. It seems more dissociative than LSD and reminds me more of mushrooms which makes since because n,n-DMT is related to psilocybin which is 4-hydroxy-dimethyltryptamine. To try and sum up the events which took place when a friend and I tried the pharmahuasca here goes:

My friend (lets call him T) comes over to my place after we pick out a day to devote to this experience. Almost every time I have tripped, Iíve done it with T. The first time I ever tripped was with T on a hit of LSD and weíve been kindred seekers of divine knowledge ever since. So I pick T up at ten in the morning and we take 250mg of the harmala extract. Itís a half hour drive to the country before we make it to my house. Safely there we take the DMT at eleven a.m. half an hour after the harmala. We each take roughly 120mg each but the scale I have isnít very precise so Iím not sure how accurate it was but I'm certain the dose was between 100 and 150mg.

We start playing our instruments, heís on guitar Iím playing my drumset. About forty minutes after dropping the D I start feeling the typical body load which I got when smoking DMT, this I do not care for and was hoping Pharmahuasca wouldnít be so body loading but it was only an inconvenience. Forty five minutes in I start noticing I am definitely tripping but start feeling nauseated. I run to the toilet and threw up. This was unexpected because I had taken rue extract and DMT separately and never got sick from either and wasnít expecting it from the combination, especially considering the purity of the extractions.

Immediately after vomiting I am tripping my waffles off! I didnít expect such strong effects from the dosage I had taken. I go to my room and lay down to cool off and try and get my heart rate down. I was headlong into a bad trip in less than an hour after dropping! I have never had a bad trip, Iíve had the fear, of course but it was always fleeting and never had I been this afraid. I try to calm myself and control my heart rate. T comes into the room, I try and act like Iím just sick at my stomach so not as to make him afraid, the last thing I want to do is bring someone else down. I admit that I am tripping hard but am feeling bad. He is amazed that Iím tripping at all because he is almost sober. T ate a big meal before this and I didnít so I knew it would take longer for his to kick in but after an hour and a half he should have been feeling something.

I mention that the buprenorphine I take may be potentiating it. He asks if he can take some to kick his in. I know he loves to trip but seeing the condition I was in I was surprised that he wanted to go where I was. I give him half a sub and tell him to let it dissolve under his tongue. While he does that I continue to lay reclined in a chair covered up, feeling sick and tripping balls. The closed eye visuals were complex and moving too fast to make sense of. I was fighting the trip but I knew I shouldnít so I tried to let go and embrace it but the sickness just fills me with negative energy and my attempts were futile. I felt like I was dying but knew that I wasnít. I am terrified that I am about to endure six more hours of this hell. T realizes that Iím in a bad place and starts talking to me about whatís going on in his life. Iím glad heís talking because it distracts me from the terrible reality unfolding before my minds eye. We have a pretty introspective conversation and he convinces me to join him for a walk in the woods. I reluctantly agree, feeling that a change of scenery may help but Iím afraid to leave my sanctuary. He talks me into smoking a little bud. I know the bud will be good for the nausea but am afraid of the increased heart rate as my heart is racing already.

After smoking I felt surprisingly better. We went hiking in the woods behind my house. Everything is profound and beautiful and so colorful. We have a great hike and come back inside to listen to some Smashing Pumpkins and trip out. After we settle down T admits that heís having trouble, he is now tripping very hard and is going to the dark place he just saved me from. For a while I try and encourage him and ease his mind but he has a difficult time for a couple hours. I start suspecting that the buprenorphine is potentiating the DMT, however Iím not sure how much of his delayed onset was due to his pre-trip meal and how much could be attributed to the D.

For the rest of the day my trip was very mild, and it surprised me how strong the trips was for an hour then how weak it became, especially since T was tripping hard the whole day. I think because I had taken my bupe early in the day and because of my high tolerance for it, that it may account for why my trip wore off so quick and his lasted, since he had no tolerance for bupe and took 4mg right after he took his DMT. More research needs to be done about the possible interaction, although Iím not crazy about being the guinea pig. Also since I purged it may have caused my trip to wear off, although T got very sick he was never able to purge. I felt like the purge was therapeutic and was just part of the experience, a cleansing. Overall the experience was enjoyable. We were only testing the waters and I want to try a higher dosage in order to break through but am afraid at the same time, since I had such horrible anxiety during the beginning if this trip, what could be expected from a proper dose?

90% of the trip was a positive experience, very spiritual but lacking something. I didnít get the ego death I was expecting, but I think I will once I take a full dose.

Exp Year: 2011ExpID: 91053
Gender: Male 
Age at time of experience: 22 
Published: Dec 22, 2020Views: 495
[ View as PDF (for printing) ] [ View as LaTeX (for geeks) ] [ Switch Colors ]
Pharmahuasca (822), Syrian Rue (45) : Small Group (2-9) (17), Bad Trips (6), Combinations (3)

COPYRIGHTS: All reports are copyright Erowid.
TERMS OF USE: By accessing this page, you agree not to download or analyze the report data without contacting Erowid Center and receiving written permission prior to your downloading the data.

Experience Reports are the writings and opinions of the individual authors who submit them.
Some of the activities described are dangerous and/or illegal and none are recommended by Erowid Center.

Experience Vaults Index Full List of Substances Search Submit Report User Settings About Main Psychoactive Vaults