Review Erowid at
Help us be a "Top Rated Nonprofit" again this year and spread
honest info (good or bad) about psychedelics & other psychoactive drugs.
("Share Your Story" link. Needs quick login creation but no verification of contact info)
The Good The Bad and The Ugly
5-HTP & Cannabis
Citation:   NotoriousBRY. "The Good The Bad and The Ugly: An Experience with 5-HTP & Cannabis (exp103300)". Sep 25, 2019.

T+ 0:00
100 mg oral Tryptophan - 5-HTP (capsule)
  T+ 0:35   smoked Cannabis  
  T+ 0:00 40 mg oral Pharms - Fluoxetine (daily)
  T+ 0:00 100 mg oral Pharms - Lamotrigine (daily)
I first heard about 5-HTP a few months prior to my experience through a friend T telling me about our other friend O taking it and it making him feel more focused and generally pretty uplifted/chilled out. I've been going through a pretty rough patch concerning my mental well-being so I was willing to try pretty much anything to help which was when I remembered 5-HTP. So, after deliberating about it for a while I finally got round to buying a bottle of 90 x 100mg capsules two days ago from a health store for around 16.

I currently take 100mg of lamotrigine as a mood stabiliser, 40mg of fluoxetine, and a generic shop-bought multivitamin. I did my research before and, from what I've read, it doesn't seem like 5-HTP and lamotrigine/fluoxetine react negatively in any way apart from possible serotonin syndrome (but at the dosage I'm taking I don't think that would happen). So at around 12:45pm I read the bottle which instructed me to take between 1-3 tablets a day on an empty stomach. I hadn't eaten since around 8pm the previous night (which may explain the negative effects)
I hadn't eaten since around 8pm the previous night (which may explain the negative effects)
so I proceeded to take one 100mg capsule of 5-HTP and set about writing up lecture notes.

About 5 minutes in I noticed I felt more focused on my work and I was powering through and writing more than I would have without that feeling. I had developed a slight headache but that may have been due to being a little dehydrated. Around 30 minutes later I finished my notes up as I was pretty hungry and getting that almost queasy feeling I get when hungry. I rolled a joint (I always like a smoke before eating) and went downstairs to make some lunch. The queasy feeling got progressively worse and I began to get those awful cold sweats along with a burning forehead. Eventually I went and knelt in front of the toilet and forced myself to be sick, but of course only a tiny bit of bile came up. I grabbed a drink of water and poured my now-ready soup into a bowl and headed upstairs still feeling awful.

Now let me point out I am a seasoned weed smoker, I usually get through two 20 bags a week so I thought smoking a joint would make me feel better. Oh man, was I wrong. I felt like a weed virgin - my head felt cold and I was sweating profusely feeling sicker than ever, and I looked incredibly pale. I took a few spoonfuls of soup and a mouthful of water thinking maybe it was just because I was so hungry. Nope. I grabbed my bin and deposited into it the soup, water, and some more stomach acid. As soon as I was sick I felt so much better, I even managed to finish my soup! After this episode I felt pretty chilled out and was able to enjoy being stoned.

While I was throwing up I was thinking to myself 'I will never try this shit again!' But now I think I might because it does have benefits, just probably not right before sparking up. I would also eat something 2-3 hours before taking any 5-HTP so my stomach's not quite as empty!

Exp Year: 2014ExpID: 103300
Gender: Female 
Age at time of experience: 21
Published: Sep 25, 2019Views: 1,956
[ View PDF (to print) ] [ View LaTeX (for geeks) ] [ Swap Dark/Light ]
Tryptophan - 5-HTP (196) : Alone (16), Difficult Experiences (5), Combinations (3), First Times (2)

COPYRIGHTS: All reports copyright Erowid.
No AI Training use allowed without written permission.
TERMS OF USE: By accessing this page, you agree not to download, analyze, distill, reuse, digest, or feed into any AI-type system the report data without first contacting Erowid Center and receiving written permission.

Experience Reports are the writings and opinions of the authors who submit them. Some of the activities described are dangerous and/or illegal and none are recommended by Erowid Center.

Experience Vaults Index Full List of Substances Search Submit Report User Settings About Main Psychoactive Vaults