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by Erowid
Caution :   Reactions and experiences may vary dramatically from person to person. [see below]
  • "kinda like K, but less in-your-face"
  • euphoria, mood lift
  • Sense of calm and serenity
  • Mild stimulation
  • Distortion or loss of sensory perceptions (common)
  • Closed- and open-eye visuals (common)
  • Dissociation of mind from body
  • Change in perception of time
  • Increase in heart rate and blood pressure
  • Confusion, disorientation
  • Out-of-body experience
  • Shifts in perception of reality
  • Short attention span
    (likelihood of negative side effects increases with higher doses)
  • Risk of psychological dependency (tentative)
  • Nasal discomfort upon insufflation
  • Blacking out and forgetting one has taken a drug
  • Severe confusion, disorganised thinking
  • Frightening or untimely distortion or loss of sensory perception
  • Susceptibility to accidents (from uncoordination and change in perception of body and time)
  • Severe dissociation, depersonalisation
  • Seizures (or seizure-like reactions) have been reported
  • Dangerous increase in heart rate and blood pressure (at higher doses)
General Effects Notes
The effects of methoxphenidine are usually compared to ketamine or methoxetamine, but there are too few experience reports with reliably sourced material to say much with confidence.

Addiction and Compulsive Use
It is not yet known how addictive or likely methoxphenidine is to cause compulsive use.

[60 mg oral] "after initial rough dose of 60 mg feeling nice and relaxed getting lost in movie avatar, xbut some points cant focus keep getting lost in my head about problems I have going on at the moment seem to be effecting experience anxiety levels arise feeling somewhat paranoid possibly because my mum is upstairs and may well come down at any Time was this a stupid idea to take while not home alone will my mum come down and realise I've taken something? Scared!!," -- Exp 104885
[100 mg oral] "Closing my eyes makes me feel as though I'm gone completely. I find the space quiet and mild in the visual department. Feels similar to MXE but less inebriating and confusing. Very relaxed but bubbly and optimistic. [...] Relaxing with my eyes closed causes my body to drift about in a similar fashion to other dissociatives. The speed of the drifting seemed quicker than MXE, but this is purely subjective so who knows." -- Exp 89972
[150 mg oral] "Around midnight, the visual changes get more noticeable. It's not hallucinogenic, I'm not seeing anything that isn't there strictly. But aspects of my vision go way way off. When I stare at my phone screen, it seems really far away from my face. The space between me and my phone is enormous. Is my arm really long now? No: I look at my arm and can snap out of it, but then I look at my screen and it's way over in the neighbouring village now." -- Exp 106528
[repeated, insufflated] "Insufflate another 50mg, bringing the total to 160mg. [...] Start to feel noticeably dissociated and definite robowalking. Decide to go lay down in a dark room by myself. Try to listen to music but I am not really interested. Not quite at the hole-ing stage (not sure if it has a hole in the same sense that other dissociatives do, but I didn't get there)." -- Exp 90919
Erowid's effects information is a summary of data gathered from users, research, and other resources. This information is intended to describe the range of effects people report experiencing. Effects may vary dramatically from one person to another or one experience to another based on a variety of factors such as body chemistry, age, gender, physical health, dose, form of material, etc.