Fundamental #13: Note changes in health over time
that may be related to psychoactive drug use.

Erowid References Database

Derungs A, Schietzel S, Meyer MR, Maurer HH, Krähenbühl S, Liechti ME. 
“Sympathomimetic toxicity in a case of analytically confirmed recreational use of naphyrone (naphthylpyrovalerone)”. 
Clinical Toxicology. 2011;.
Abstract
Context. Naphyrone (naphthylpyrovalerone) is a cathinone derivative and recreational drug related to mephedrone. Case. We report a 31-year-old man who ingested a dose of naphyrone (100 mg), which produced acute sympathomimetic toxicity with restlessness, insomnia, anxiety, and hallucinations lasting for 2 days. Naphyrone was detected in the patient's plasma by gas chromatography with mass spectrometry at concentrations of 0.03 and 0.02 mg/L, 40 and 60 h after drug intake, respectively. Discussion. Based on the present case report and user web-reports, as well as on the chemical structure and pharmacological characteristics, naphyrone produces stimulant-like psychotropic effects and sympathomimetic toxicity.


Key Words: CNS, amphetamine, stimulant, drug abuse, pharmacokinetics
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