Pharmacological studies of the substances reported in the earlier papers of this series having shown that considerable value as pressors is exhibited by the primary and secondary β-hydroxy-β- (2,5-dimethoxy)-phenylethyl and phenylisopropylamines,
it was of interest to compare these with the analogous substances in which the 5-
methoxyl group was exchanged for a methyl group. At the same time the preparation of 2-hydroxy-5-methyl analogs by using the benzyl group for protection proved to be feasible although offering some experimental difficulties in the earlier part of the work.
