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Soskin RA, Grof S, Richards WA.
“Low Doses of Dipropyltryptamine in Psychotherapy”.
Arch Gen Psychiat. 1973;28(6):817-21.
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Abstract
The efficacy of dipropyltryptamine (DPT) treatment, as an adjunct to psychotherapy, was tested under double-blind conditions in 18 alcoholic subjects. Methods DPT is a hallucinogenic drug with a shorter duration of action, and more abrupt termination than LSD. Assessment program involved 1 or 2 drug-free interviews, followed by 6-8 interviews at which DPT (15-20 mg i.m.), or placebo, were administered. Initial dose was subsequently increased by 5 mg increments until optimum effect was judged to have been attained. In all, 11 doses at is mg, 38 at 20 mg, 17 at 25 mg and 6 at 30 mg were given. Effect was assessed by standard psychotherapy rating scales, and patient assessment was obtained at the end of each interview. Average duration of interview was 2 hr. Average age of the subjects was 38 yr. Results DPT-assisted therapy was superior to placebo therapy on, both therapist and patient ratings. DPT significantly enhanced recall of memories and experiences, increased the depth of self-exploration, and helped towards a better psychodynamic resolution. Patient ratings also suggested that DPT sessions to were more productive. Threshold dose was between 10 and 15 mg but a regime in which 15 or 20 mg was given initially, and then followed by 2 or more drug-free interviews, produced best con - ditions for psychotherapeutic resolution.
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