LSD given to 14 healthy controls, 12 patients with predominant depression and 7 patients with schizophrenia. Clinically, the changes produced resembled those previously described. In general, slight although clinically apparent changes due to LSD were difficult to verify objectively. However, spectroscopic oximetry (an estimate of capillary change) indicated increased autonomic lability in the controls, and depressives but not in the schizophrenics. The "efficiency score" (of oximetric studies) was very significantly raised in the depressive group, but unchanged in the schizophrenics, and only slightly raised in the healthy controls.
