The effect of some factors which modify experimental tuberculin hypersensitivity in guinea pigs was studied in 10 patients with rheumatoid arthritis and one patient with polyarteritis nodosa. In 3 cases ascorbic acid depletion and saturation did not influence the course of rheumatoid arthritis or the effects of Cortisone and ACTH. Glucose-l-phosphate did not influence the course of the arthritis in 4 cases or the tuberculin reaction in the 2 cases tested. LSD did not influence the course of rheumatoid arthritis in 4 patients or the tuberculin reaction in the 2 cases tested. Gluce-l-phosphate and LSD had no effect on eosinophil counts or erythrocyte sedimentation rates.
