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Ayahuasca
Timeline
by Erowid
1841 Harmaline first synthesized from Syrian rue.   
1852 Earliest known western record of the psychoactive effects of ayahuasca (Banisteriopsis caapi) in the Brazilian Amazon. 1   Details
1858 First widely read description of yage practices was published. 2  
1923 A film of South American yage ceremonies was shown at the annual meeting of the American Pharmaceutical Association.   
1968 Holmstedt, Lindgren, and Agurell hypothesize that the effects of ayahuasca are caused by a combination of naturally occurring monoamine oxidase inhibitors and DMT. 3  


References
  1.   Spruce, R. In: Wallace, AR (Ed.) Notes of a Botanist on the Amazon and Andes. London: Macmillan. 1908; and: Spruce, R. "Ocean Highways". Geographical Review n.s. No. 55(Aug):184. 1873. As cited in Schultes, RE. "The beta-Carboline Hallucinogens of South America" Journal of Psychoactive Drugs 14(3):205-220. 1982.
  2.   Stafford P. Psychedelics Encyclopedia. Ronin, 1992.
  3.   Ott, J. "Pharmahuasca, Anahuasca and Vinho da Jurema: Human Pharmacology of Oral DMT Plus Harmine". Yearbook for Ethnomedicine. 1997/98.