A summary is presented of human self-experiments or psychonautic bioassays of pharmahuasca capsules containing crystalline N,N-dimethyltryptamine (DMT) plus harmine, as well as combinations of other psychoactive tryptamines with other beta-carbolines. The 1967 HOLMSTEDTLINDGREN hypothesis of the ayahuasca effect-oral psychoactivity of DMT consequent to monoamine-oxidase [MAO] inhibition from concomitant ingestion of beta-carbolines- has been confirmed by 8 self-experimenters. Results of a total of some 70 bioassays are summarized and the literature on this subject is reviewed. Discussion of ayahuasca analogues (anahuasca) focuses on the contemporary non-traditional use of jurema preta (Mimosa tenuiflora) and the ethnobotany and human pharmacology of traditional vinho da jurema is also reviewed [with 94 references and 1 Table].
