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Seiden LS, Woolverton WL, Lorens SA, Williams JEG, Corwin RL, Hata N, Olimski M. 
“Behavioral consequences of partial monoamine depletion in the CNS after methamphetamine-like drugs: the conflict between pharmacology and toxicology”. 
NIDA Res Monogr. 1993;136:34-46.
Methamphetamine(MA) and certain related phenethylaminesare drugs of abuse that are toxic to DA- and/or 5-HT-containing neurons in the brain (Hotchkiss et al. 1979; Koda and Gibb 1973; Selden et al. 1976; Selden and Kleven 1989). When administered repeatedly to animals, these compounds induce long-lasting monoamine depletions on the order of 50 percent. It seems likely that these drugs are neurotoxic in humans. Therefore, it is important to determine whether monoamine depletions of the magnitude produced by these drugs have significant behavioral consequences. Although these compounds have been found to have little or no obvious long-lasting effect on behavior, behavioral testing has not been extensive. Therefore,the present series of experiments was designed to examine the effects of small-to-moderate depletions of DA and 5-HT induced by neurotoxins or neurotoxic amphetamines on a wide range of behaviors that were predicted to be sensitive to small changes in monoamine concentrations. Those behaviors included locomotion, feeding, drinking, avoidance, escape, and open-field testing as well as several different operant tasks that are known to be sensitive to antidepressant, anxiolytic, andantipsychotic drugs.
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