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Schmidt CJ, Wu L, Lovenberg W. 
“Methylenedioxymethamphetamine: a potentially neurotoxic amphetamine analogue”. 
Eur J Pharmacol. 1986;124(1-2):175-8.
The amphetamine analogue, methylenedioxymethamphetamine (MDMA) has received considerable attention recently as a novel and increasingly popular psychoactive agent. When administered acutely to rats in high doses, MDMA caused a selective and dramatic decrease in brain concentrations of serotonin and its metabolite, 5-hydroxyindoleacetic acid. The depletion of serotonin and its metabolite persisted for up to at least one week after a single injection of MDMA at approximately four to five times the acute dose reported for humans. These results are discussed in terms of the possible neurotoxic effects of MDMA.
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