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Stafford P. 
“Re-creational Uses of LSD”. 
J Psychoactive Drugs. 1985 Oct-Dec;17(4):219-228.
[Excerpt] Right from the beginning, lysergic acid diethylamide (LSD) was ingested for nonmedical reasons and produced an experience that was re-creational in nature. Since that day of April 19, 1943, when Albert Hofmann “determined to probe the situation,” this molecule was confined to research labs at Sandoz Pharmaceuticals in Basel, Switzerland, until the late 1940’s. There it was given to six schizophrenics on 20 occasions (which might be viewed as medical use) and to 16 normal subjects on 29 occasions (more likely, re-creational use). Although investigative dosages of only 20 to 30 micrograms (μg) were used after Hofmann’s trip, these 23 people constituted the entire first sampling of impressions on how this new substance might be applied.
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