Erowid References Database
“Synthesis of Hexahydrobenzodipyrans as Ring-Expanded Analogues of Potent Serotonin 5-HT2A/2C Receptor Probes”.
UW-La Crosse JUR. 1999;II.
Substituted hexahydrobenzodipyrans were designed as molecular probes for determining the steric restrictions of the agonist binding site of serotonin 5-HT2A and 5-HT2C receptors. The rationale for the design of these novel receptor ligands, and their chemical synthesis, is described here. Upon completion of their synthesis
these compounds will be evaluated for their in vivo behavioral activity in rats and for their affinity for cloned human 5-HT2A/2C receptors in vitro. The results of these studies will provide information about the three-dimensional structure of the 5-HT2A/2C receptor binding site. Ultimately, this work may provide a better understanding of serotonin-related mental disorders.
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