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Essawi MY. 
“Fentanyl analogues with a modified propanamido group as potential affinity labels: synthesis and in vivo activity”. 
Pharmazie. 1999 Apr 28;54(4):307-8.
Abstract
This report describes the synthesis and analgesic activity (hot-plate test) of potential affinity labels of the mu-opioid fentanyl (1) [3]. In these derivatives (2-5), the propanamido group of fentanyl was modified to include an electrophilic center which may interact with a receptor nucleophile.
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