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Parrott AC, Gibbs A, Scholey AB, King R, Owens K, Swann P, Ogden E, Stough C. 
“MDMA and methamphetamine: some paradoxical negative and positive mood changes in an acute dose laboratory study”. 
Psychopharmacology (Berl). 2011 Jun 10;215(3):527-36.
This study investigated the acute mood effects of oral MDMA, methamphetamine, and placebo in a double-blind laboratory study.

Methods Fifty-two healthy participants comprised abstinent recreational users of stimulant drugs, 27 female and 25 male, mean age 24.8 years. Three test sessions involved acute 100 mg oral 3.4-methylendioxymethamphetamine (MDMA), 0.42 mg/kg oral methamphetamine, and matching placebo. Drug administration was counterbalanced, testing was double-blind, and medical supervision was present throughout. Car-driving performance on a laboratory simulator was assessed after 3 and 24 h, with the findings being presented elsewhere. Positive and negative moods (PANAS self-ratings) were completed before drug administration, 3, 4.5, and 24 h later. Blood samples were taken to monitor drug plasma levels.

Results Following MDMA, there were no significant increases in positive moods, whereas negative moods were significantly higher than under placebo. Methamphetamine led to significant increases in both positive and negative moods. The MDMA findings contrast with the elated moods, typically noted by dance clubbers on Ecstasy. However, they are consistent with some previous laboratory findings, since a wide array of positive and negative mood changes have been demonstrated. One possible explanatory factor was the neutral environmental situation, particularly if a primary action of MDMA is to intensify ongoing psychological states. Other explanatory factors, such as dosage, gender, post-drug timing, neurohormonal aspects, and social factors, are also discussed.

Conclusions In the laboratory, acute methamphetamine led to significantly higher positive moods. However, against expectations, MDMA did not generate a significant increase in positive moods.
Comments and Responses to this Article
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May 14, 2013 20:28
Parrott et al give MDMA-naive Humans MDMA #

In this study, participants needed to only have prior experience with amphetamine-type drugs. Accordingly, they gave MDMA to two people who were previously MDMA-naive. Parrott and other authors have argued that there is no safe level of MDMA use, including Parrott's solo 2013 paper "MDMA, serotonergic neurotoxicity, and the diverse functional deficits of recreational 'Ecstasy' users".
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