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Siegel RK, Jarvik ME. 
“DMT self-administration by monkeys in isolation”. 
Bull Psychonomic Soc. 1980 Aug;16(2):117-120.
Three rhesus monkeys trained to smoke lettuce cigarettes for water reward extinguished responding when given water ad lib or when the hallucinogen dimethyltryptamine (DMT) was added to the lettuce. Ss were then individually confined to an operant unit placed in a sensory isolation chamber that deprived them of light and sound but permitted infrared video monitoring. After continuous isolation for several days, 2 Ss consistently self-administered DMT in performance marked by dramatic changes in perceptual-motor behaviors. These results suggest that animals will self-administer a hallucinogen when it provides stimulation in an otherwise deprived environment.
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