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Jones RT, Maddock R, Rarrell TR, Herning R. 
“Marijuana And Human Thermoregulation In A Hot Environment”. 
Thermoregulatory Mechanisms and Their Therapeutic Implications (eds. B. Cox, Manchester; P. Lomax, Los Angeles, Calif.; A.S. Milton, Aberdeen, and E. Schoenbaum, Oss). 1980.
INTRODUCTION: In adult humans, thermoregulation is more resistant to disruption than in smaller animals. Below a critical ambient temperature (e.g., 34C for dogs), marijuana or tetrahydrocannabinol (THC) induce hypothermia in laboratory animals, While above that temperature hyperthermia results [1]. Studies of marijuana on human body temperature in a normal or cool environment found no change or decreases of 0.1 to O.2C [2,3]. However, we found that marijuana consistently increases body temperature at a high (40C) ambient temperature.

METHODS: Six Subjects smoked a marijuana cigarette (900 mg) containing THC (18 mg) and 6 subjects smoked a placebo marijuana cigarette in a room maintained at 402C. A second group of 12 subjecta smoked both a marijuana and a placebo cigarette in random order J at an ambient temperature of 231C [5]. All were male, experienced marijuana users. Body temperature was recorded for 2 h after smoking at the tympanic membrane and the finger together with forearm skin conductance J heart rate and subjective Intoxication ratings. Pre-drug baaeline involved 1 h in the hot room including at least 20 min immediately prior to smoking. During thia time the subjects sweated continuously and body temperature varied only 0.1C . In the second experiment, the base-line period was 20 min as the subject sat quietly at normal room temperature. Core temperature increased an average of O.5C shortly after entry into the hot room, accounting for the higher pre-smoking baseline temperatures seen in these sUbjects.

RESULTS: Core temperature increased after smoking marijuana (p < 0.01) at an ambient temperature of 40C (Fig. 1a). Individuals had increases of from 0.6C to 1.3C. After amoking marijuana at an ambient temperatUl'e 23C, core temperature initially decreased O.2C and later increased O.3C (Fig. lb). The magnitude and timing of the changes were different from those at 40C ambient temperature. Placebo had no effect in either thermal environment.
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