Erowid References Database
Fuller RW, Hines CW, Mills J.
“Lowering of Brain Serotonin Levels by Chloramphetamines”.
Biochem Pharmacol. 1965 Apr 01;14:483-8.
Abstract-l-Chloroamphetamine and several structurally similar compounds lowered serotonin level in the whole brain of rats without lowering the level of norepinephrine. Relationships between chemical structure of chloroamphetamines and their effects on brain serotonin level are presented. There was no difference between the effects of
dextrorotatory and levorotatory isomers of 4-chloromethamphetamine. 4-Chloroamphetamine lowered serotonin but not norepinephrine level in the septum-diencephalon-midbrain area of dog brain.
4-Chloroamphetamine did not inhibit tryptophan hydroxylation in rat liver or bacterial preparations nor did it inhibit the uptake of 14C-5-hydroxytryptophan into rat brain. The lowering of brain serotonin level does not appear to be a result of decreased serotonin synthesis but may be due to an unusual type of release of serotonin.
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