Plants - Drugs Mind - Spirit Freedom - Law Arts - Culture Library  
Erowid References Database
Frances H. 
“Psychopharmacological profile of 1-(m-(trifluoromethyl) phenyl) piperazine (TFMPP)”. 
Pharmacol Biochem Behav. 1988 Sep 08;31(1):37-41.
The effect of TFMPP, an agonist of the 5-HT1b receptors, was studied in mice on several psychopharmacological parameters. In contrast to imipramine-like drugs, TFMPP neither antagonized reserpine-induced hypothermia nor increased yohimbine-induced toxicity. Similarly to imipramine-like drugs, TFMPP antagonized oxotremorine-induced hypothermia and was active in the behavioural despair test. In addition, TFMPP normalized a social behavioural deficit induced by isolation. The effects of TFMPP on oxotremorine-induced hypothermia in the behavioural despair test and in the isolation-induced social behavioural deficit are all antagonized by d-1 propranolol. It is concluded that TFMPP seems to possess psychotropic activity resembling only in part that of imipramine-like drugs and that these actions may be mediated through 5-HT1b receptors.
Comments and Responses to this Article
Submit Comment
[ Cite HTML ]