Plants - Drugs Mind - Spirit Freedom - Law Arts - Culture Library  
Erowid References Database
Feng Z, Mohapatra S, Klimko PG, Hellberg MR, May JA, Kelly C, Williams G, McLaughlin MA, Sharif NA. 
“Novel benzodifuran analogs as potent 5-HT2A receptor agonists with ocular hypotensive activity”. 
Bioorg Med Chem Lett. 2007 Jun 14;17(11):2998-3002.
A series of 8-substituted benzodifuran analogs was prepared and evaluated for 5-HT(2A) receptor binding and activation. Several compounds containing ether and ester functionality were found to be potent agonists. Topical ocular administration of 5, 18, and 25 effectively reduced intra-ocular pressure in the hypertensive cynomolgus monkey eye in the range of 25-37%.
Comments and Responses to this Article
Submit Comment
[ Cite HTML ]