Erowid
 
 
Plants - Drugs Mind - Spirit Freedom - Law Arts - Culture Library  
Erowid References Database
Ewald AH, Fritschi G, Maurer HH. 
“Designer drug 2,4,5-trimethoxyamphetamine TMA-2: studies on its metabolism and toxicological detection in rat urine using gas chromatographic/mass spectrometric techniques”. 
J Mass Spectrom. 2006 Sep 18;41(9):1140-8.
Abstract
Studies are described on the metabolism and the toxicological detection of the amphetamine-derived designer drug 2,4,5-trimethoxyamphetamine TMA-2 in rat urine using gas chromatographic/mass spectrometric GC/MS techniques. The identified metabolites indicated that TMA-2 was metabolized by oxidative deamination to the corresponding ketone followed by reduction to the corresponding alcohol, O-demethylation followed by oxidative deamination, and finally O,O-bis-demethylation. All metabolites carrying hydroxy groups were found to be partly excreted in urine as glucuronides and/or sulfates. The authors' systematic toxicological analysis STA procedure using full-scan GC/MS after acid hydrolysis, liquid-liquid extraction, and microwave-assisted acetylation allowed the detection, in rat urine, of an intake of TMA-2 that corresponds to a common drug users' dose. Assuming similar metabolism, the described STA procedure in human urine should be suitable as proof of an intake of TMA-2.
Comments and Responses to this Article
#
Submit Comment
[ Cite HTML ]