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Demisch L, Seiler N. 
“Oxidative metabolism of mescaline in the central nervous system--V In vitro deamination of mescaline to 3,4,5-trimethoxy-benzoic acid”. 
Biochem Pharmacol. 1975 Mar 03;24(5):575-80.
3,4,5-Trimethoxy-benzoic acid 3,4,5-TMBA besides 3,4,5-trimethoxy-phenylacetic acid 3,4,5- TMPAA is formed from mescaline during its incubation with preparations of different mouse tissues. Brain has the highest capacity to form 3,4,5-TMBA among the tissues so far studied. The enzyme system which catalyses the oxidative deamination of mescaline to 3,4,5-TMBA is localized in the nuclear and microsomal fractions of brain. Oxygen, NADPH and unidentified factors of the high speed supernatant of brain extract are necessary for optimal reaction conditions. 3,4,5-TMBA formation was inhibited by SKF 525-A, but not by MAO and DA0 inhibitors. The similarities and dissimilarities of the enzymic deamination of amphetamine and mescaline are discussed.
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