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Dabiré H, Chaouche-Teyara K, Cherqui C, Fournier B, Schmitt H. 
“DOI is a mixed agonist-antagonist at postjunctional 5-HT2 receptors in the pithed rat”. 
Eur J Pharmacol. 1989 Oct 06;170(1-2):109-11.
The maximal pressor effect induced by DOI in the pithed rat was smaller than that induced by 5-HT, suggesting partial agonistic properties of DOI. DOI shifted the dose-pressor response curve of 5-HT to the right. It is concluded that, in addition to its 5-HT2 agonistic properties, DOI also possesses 5-HT2 antagonistic properties in the pithed rat.
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