Plants - Drugs Mind - Spirit Freedom - Law Arts - Culture Library  
Erowid References Database
Dabiré H, Chaouche-Teyara K, Cherqui C, Fournier B, Laubie M, Schmitt H. 
“Characterization of DOI, a putative 5-HT2 receptor agonist in the rat”. 
Eur J Pharmacol. 1989 Sep 03;168(3):369-74.
DOI 1-100 micrograms/kg i.v. induced an increase in mean blood pressure in the anaesthetized rat. Similarly, in the pithed rat, DOI 1-100 micrograms/kg i.v. induced a dose-dependent increase in mean blood pressure, as did 5-HT. However, in contrast to 5-HT, DOI did not change the heart rate in either intact or pithed rats. In the pithed rat, the dose-pressor response curves to both 5-HT and DOI were unaffected by MDL 72222 5-HT3 receptor antagonist, spiroxatrine or +/--pindolol 5-HT1A receptor antagonists, idazoxan alpha 2-adrenoceptor blocking agent and AR-C 239 alpha 1-adrenoceptor blocking agent. Only the selective 5-HT2 receptor antagonist. LY 53857, significantly and dose dependently shifted to the right the dose-response curves to both 5-HT and DOI. These results indicated that DOI possesses 5-HT2 agonistic properties and that the pressor response induced by DOI in the pithed rat is mediated via 5-HT2 receptors.
Comments and Responses to this Article
Submit Comment
[ Cite HTML ]