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Chaouloff F, Baudrie V, Layeillon C, Broqua P. 
“The 5-HT2 receptor agonist 1-2,5-dimethoxy-4-iodophenyl2-aminopropane increases brain tryptophan levels in the rat”. 
Eur J Pharmacol. 1992 Apr 16;214(1):101-3.
Earlier studies have indicated that the sympathoadrenal system and the corticotropic axis control brain levels of tryptophan Trp, the precursor of 5-hydroxytryptamine 5-HT. We investigated the effects of 5-HT receptor agonists known to activate the sympathoadrenal system and/or the corticotropic axis on plasma and brain Trp levels. Neither the 5-HT1A receptor agonist 8-hydroxy-2-di-n-propylaminotetralin 8-OH-DPAT, 0.5 mg/kg s.c., nor the 5-HT1C receptor agonist 1-3-chlorophenylpiperazine mCPP, 2.5 mg/kg s.c. affected plasma and brain Trp levels. The 5-HT2 receptor agonist 1-2,5-dimethoxy-4-iodophenyl2-aminopropane DOI, 0.5-2 mg/kg s.c. increased brain Trp levels, an effect which was significant for the two highest doses used 1.5-2 mg/kg s.c..
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